Gut-Brain Axis in Gastric Mucosal Damage and Protection

Author(s): Dolores Sgambato, Annalisa Capuano, Maria Giuseppa Sullo, Agnese Miranda, Alessandro Federico, Marco Romano.

Journal Name: Current Neuropharmacology

Volume 14 , Issue 8 , 2016

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Abstract:

Background: The gut-brain axis plays a potential role in numerous physiological and pathological conditions. Several substances link stomach with central nervous system. In particular, hypothalamo-pituitary-adrenocortical axis, thyrotropinreleasing factor-containing nerve fibers and capsaicin-sensitive nerves are principal mediators of the harmful and protective central nervous system-mediated effects on gastric mucosa. Also, existing evidence indicates that nitric oxide, prostaglandins and calcitonin gene-related peptide play a role as final effectors of gastric protection.

Methods: We undertook a structured search of bibliographic databases for peerreviewed research literature with the aim of focusing on the role of gut-brain axis in gastric damage and protection. In particular, we examined manuscripts dealing with the role of steroids, thyrotropin-releasing hormone, prostaglandins, melatonin, hydrogen sulfide and peptides influencing food intake (i.e. leptin, cholecystokinin, peptide YY, central glucagon–like peptide-1, and ghrelin). Also, the role of GABAergic and glutamatergic pathways in gastric mucosal protection have been examined.

Results: We found and reviewed 61 peer-reviewed papers dealing with the major aspects related to the role of gut brain axis in gastric mucosal damage and protection.

Conclusions: A dense neuronal network links stomach with central nervous system and a number of neurotransmitters and peptides functionally and anatomically related to central nervous system play a major role in contributing to gastric mucosal integrity.

Exploiting the mechanisms underlying the connection between brain and gut may lead to a better understanding of the pathophysiology of gastric mucosal injury and to an improvement in the prevention and, eventually, management of gastric damage.

Keywords: CNS, gastric damage, gastric protection, gut-brain, hydrogen sulfide, melatonin, thyrotropin-releasing hormone.

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Article Details

VOLUME: 14
ISSUE: 8
Year: 2016
Page: [959 - 966]
Pages: 8
DOI: 10.2174/1570159X14666160223120742
Price: $58

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