Population Studies of Association Between Lithium and Risk of Neurodegenerative Disorders

Author(s): Markus Donix, Michael Bauer.

Journal Name: Current Alzheimer Research

Volume 13 , Issue 8 , 2016

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Abstract:

Background: Lithium shows neuroprotective and neurotrophic effects in vitro and in vivo. Due to its involvement in hippocampal neurogenesis and the interaction with beta-amyloid and neurofibrillary tangle metabolism it has been hypothesized that lithium could have the potential to influence the development of dementia. Method: Using the PubMed database and cross-reference search strategies our aim was to specifically identify population (cohort or case-control) studies investigating the association between lithium and dementia. Results: Data from large cohort studies suggest an association between lithium treatment and dementia risk reduction or reduced dementia severity. Studies with smaller sample sizes yield more variable findings. Conclusions: Lithium may reduce the risk of dementia among middle-aged and older people. Beneficial lithium effects are possibly limited to specific types of neurodegenerative processes.

Keywords: Alzheimer’s disease, dementia, lithium, neuroprotection, population studies, risk reduction.

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Article Details

VOLUME: 13
ISSUE: 8
Year: 2016
Page: [873 - 878]
Pages: 6
DOI: 10.2174/1567205013666160219112957
Price: $58

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