Lithium Distinctly Modulates the Secretion of Pro- and Anti- Inflammatory Interleukins in Co-Cultures of Neurons and Glial Cells at Therapeutic and Sub-Therapeutic Concentrations

Author(s): Vanessa J. De-Paula , Daniel S. Kerr , Gustavo Scola , Wagner F. Gattaz , Orestes V. Forlenza .

Journal Name: Current Alzheimer Research

Volume 13 , Issue 8 , 2016

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Abstract:

Lithium is associated with various effects on immune functions, some of which are still poorly understood. The roles of many cytokines have been characterized in a variety of neurodevelopmental processes including neurogenesis, neuronal and glial cell migration, proliferation, differentiation, synaptic maturation and synaptic pruning. This work aims to evaluate the effects of different doses of lithium (0.02; 0.2 and 2mM) on the secretion of cytokines in co-cultures of cortical and hippocampal neurons with glial cells. Our results indicate that chronic treatment with lithium chloride at subtherapeutic concentrations are able to modify the secretion of pro- and anti-inflammatory interleukins in co-cultures of cortical and hippocampal neurons with glial cells.

Keywords: Co-culture, cortical neurons, hippocampal neurons, lithium, neuroprotection pro- and anti-inflammatory interleukins.

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Article Details

VOLUME: 13
ISSUE: 8
Year: 2016
Page: [848 - 852]
Pages: 5
DOI: 10.2174/1567205013666160219112612
Price: $58

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