Mild Synthesis of mono-, bis- and tris 1,2-Dihydrobenzo[4,5]imidazo[1,2- a]pyrimidine Derivatives Using Alkyl Disulfamic Acid Functionalized Magnetic Nanoparticles

Author(s): Mohammad A. Bodaghifard , Zahra Faraki , Ali R. Karimi .

Journal Name: Current Organic Chemistry

Volume 20 , Issue 15 , 2016

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Abstract:

Alkyl disulfamic acid-functionalized silica-coated magnetic nanoparticles (ADSA-MNPs) have been synthesized as a hybrid organic- inorganic acidic nanoparticles and its catalytic activity has been evaluated in the synthesis of mono-, bis- and tris 1,2-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine via a one-pot three, pseudo-five or pseudo-seven component condensation reaction of aromatic aldehydes, malononitrile and 2-aminobezimidazole under solvent-free heating. The heterogeneous catalyst was facilely separated from the reaction mixture by utilizing external magnetic field and reused for several times without considerable decrease of catalytic performance.

Keywords: Nanoparticles, magnetite, heterogeneous catalysis, sulfamic acid, imidazo[1, 2-a]pyrimidine, multicomponent reaction.

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Article Details

VOLUME: 20
ISSUE: 15
Year: 2016
Page: [1648 - 1654]
Pages: 7
DOI: 10.2174/1385272820666160218233729
Price: $58

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