iPSCs Derived from Malignant Tumor Cells: Potential Application for Cancer Research

Author(s): He Cheng, Chen Liu, Xiaochen Cai, Yu Lu, Yongfeng Xu, Xianjun Yu.

Journal Name: Current Stem Cell Research & Therapy

Volume 11 , Issue 5 , 2016

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Abstract:

The development of induced pluripotent stem cell (iPSC) technology has inspired a series of methods to manipulate cell fate and has provided novel insight into the profound molecular events underlying the development of diseases. Reprogramming somatic cells into iPSCs has been intensively investigated. However, few studies have investigated the reprogramming of malignant cells and its potential application. Herein, we review the recent progress of iPSCs derived from malignant cells, and highlight tumor iPSCs applications on cancer research which mainly focus on mesenchymal-epithelial transition, genetic and epigenetic change, diseases model construction, drug screening and tumor pathway study.

Keywords: Genetics and epigenetics, induced pluripotency stem cell, malignancy, reprogramming, transcription factor.

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Article Details

VOLUME: 11
ISSUE: 5
Year: 2016
Page: [444 - 450]
Pages: 7
DOI: 10.2174/1574888X11666160217154748
Price: $58

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