Novel Therapeutic Targets for Management of Type-2 Diabetes Mellitus

Author(s): Anishkumar Chaurasia, Rashmi Mallya, Tabassum Khan.

Journal Name: Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Under Re-organization)

Volume 16 , Issue 1 , 2016

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Abstract:

A number of conventional therapeutic targets are available for treatment of Type 2 diabetes mellitus (T2DM) but due to development of resistance by using conventional drug as monotherapy, there is a need to identify novel therapeutic targets and/or use combination of conventional and novel drugs for diabetes therapy. In this review we have highlighted some of the novel approaches like inhibitors of (11- Hydroxysteroid dehydrogenase type-1, Sodium-glucose linked cotransporter-2, Acyl-CoA Diacylglycerol Acyl Transferase-1, Glycogen phosphorylase-A, Pyruvate Dehydrogenase Kinase, Protein tyrosine phosphate 1B, Kappa kinase-B, Stearoyl-coA desaturase-1), antagonists of (Fatty acid binding proteins, Fibroblast growth factors-21 receptor, Glucagon receptor, Glucocorticoid receptors), Glucokinase and Sirtuin activators, Cannabinoid receptor blockers, Incretin-mimetics, agonists of (Adenosine monophosphate activated protein kinase, Augmenting GLP-1 secretion GPR40, GPR120, GPR 146 and TGR 5, GPCR 119, liver x receptors, Serotonin 2c receptor) and Rexinoids x receptor modulators developed for the treatment of diabetes.

Keywords: 11-Hydroxysteroid dehydrogenase type 1 inhibitors, glucagon receptor antagonist, glucokinase activators, incretin mimetics, liver x receptors, type-2 Diabetes Mellitus.

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Article Details

VOLUME: 16
ISSUE: 1
Year: 2016
Page: [18 - 30]
Pages: 13
DOI: 10.2174/1871522216666160216225721
Price: $58

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