Are Human Tyrosinase and Related Proteins Suitable Targets for Melanoma Therapy?

Author(s): Elina Buitrago, Renaud Hardré, Romain Haudecoeur, Hélène Jamet, Catherine Belle, Ahcène Boumendjel, Luigi Bubacco, Marius Réglier.

Journal Name: Current Topics in Medicinal Chemistry

Volume 16 , Issue 27 , 2016

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Abstract:

Among the human copper-containing monooxygenases, Tyrosinase (Ty) is an important enzyme involved in the determinant step of the biosynthetic pathway of melanin pigment. In this pathway, Ty catalyzes the tyrosine monooxygenation into L-DOPA-quinone, which is the precursor of the skin pigment melanin. Ty inhibitors/activators are a well-established approach for controlling in vivo melanin production, so their development has a huge economical and industrial impact. Moreover, recent publications highlight that targeting tyrosinase with inhibitors/activators to treat melanogenesis disorders is one of many possible approaches, due to the complex biochemical reaction involved in the melanin synthesis.

Keywords: Melanoma, Tyrosinase, TRP-1, TRP-2, Tyrosinase effectors.

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Article Details

VOLUME: 16
ISSUE: 27
Year: 2016
Page: [3033 - 3047]
Pages: 15
DOI: 10.2174/1568026616666160216160112
Price: $58

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