Current Topics in Medicinal Chemistry

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA


The Unexpected Advantages of Using D-Amino Acids for Peptide Self- Assembly into Nanostructured Hydrogels for Medicine

Author(s): Michele Melchionna, Katie E. Styan, Silvia Marchesan.

Graphical Abstract:


Self-assembled peptide hydrogels have brought innovation to the medicinal field, not only as responsive biomaterials but also as nanostructured therapeutic agents or as smart drug delivery systems. D-amino acids are typically introduced to increase the peptide enzymatic stability. However, there are several reports of unexpected effects on peptide conformation, self-assembly behavior, cytotoxicity and even therapeutic activity. This mini-review discusses all the surprising twists of heterochiral self-assembled peptide hydrogels, and delineates emerging key findings to exploit all the benefits of D-amino acids in this novel medicinal area.

Keywords: Chirality, D-Amino acids, Enantiomers, Heterochiral, Hydrogels, Nanomaterials, Peptides, Self-assembly.

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Article Details

Year: 2016
Page: [2009 - 2018]
Pages: 10
DOI: 10.2174/1568026616999160212120302