The Unexpected Advantages of Using D-Amino Acids for Peptide Self- Assembly into Nanostructured Hydrogels for Medicine
Katie E. Styan,
Self-assembled peptide hydrogels have brought innovation to the medicinal field, not only
as responsive biomaterials but also as nanostructured therapeutic agents or as smart drug delivery systems.
D-amino acids are typically introduced to increase the peptide enzymatic stability. However,
there are several reports of unexpected effects on peptide conformation, self-assembly behavior, cytotoxicity
and even therapeutic activity. This mini-review discusses all the surprising twists of heterochiral
self-assembled peptide hydrogels, and delineates emerging key findings to exploit all the benefits
of D-amino acids in this novel medicinal area.
Keywords: Chirality, D-Amino acids, Enantiomers, Heterochiral, Hydrogels, Nanomaterials, Peptides, Self-assembly.
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