In spite of tremendous advancement in the field of cancer therapy, it is still one of the
leading causes of death worldwide. One of the newest targets in the field of cancer therapeutics is
5’Adenosine Mono Phosphate activated protein kinase (AMPK). In vitro and in vivo evidences
suggest anti-cancer activity of AMPK. AMPK activation may promote catabolism while
preventing the anabolic processes of cell. Thus it may modulate cellular protein and lipid
metabolism and affect the growth and division of cell. Here we review the mechanisms of action
of AMPK modulators as future anti-cancer agents.
Keywords: AMPK, anti-cancer, diabetes, natural, synthetic.
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