Abstract
In spite of tremendous advancement in the field of cancer therapy, it is still one of the leading causes of death worldwide. One of the newest targets in the field of cancer therapeutics is 5’Adenosine Mono Phosphate activated protein kinase (AMPK). In vitro and in vivo evidences suggest anti-cancer activity of AMPK. AMPK activation may promote catabolism while preventing the anabolic processes of cell. Thus it may modulate cellular protein and lipid metabolism and affect the growth and division of cell. Here we review the mechanisms of action of AMPK modulators as future anti-cancer agents.
Keywords: AMPK, anti-cancer, diabetes, natural, synthetic.
Anti-Cancer Agents in Medicinal Chemistry
Title:5' Adenosine Monophosphate-Activated Protein Kinase Modulators as Anticancer Agents
Volume: 16 Issue: 8
Author(s): Abhishek Thakur, Nirnoy Dan, Soumendranath Bhakat, Venkatesan Jayaprakash and Sugato Banerjee
Affiliation:
Keywords: AMPK, anti-cancer, diabetes, natural, synthetic.
Abstract: In spite of tremendous advancement in the field of cancer therapy, it is still one of the leading causes of death worldwide. One of the newest targets in the field of cancer therapeutics is 5’Adenosine Mono Phosphate activated protein kinase (AMPK). In vitro and in vivo evidences suggest anti-cancer activity of AMPK. AMPK activation may promote catabolism while preventing the anabolic processes of cell. Thus it may modulate cellular protein and lipid metabolism and affect the growth and division of cell. Here we review the mechanisms of action of AMPK modulators as future anti-cancer agents.
Export Options
About this article
Cite this article as:
Thakur Abhishek, Dan Nirnoy, Bhakat Soumendranath, Jayaprakash Venkatesan and Banerjee Sugato, 5' Adenosine Monophosphate-Activated Protein Kinase Modulators as Anticancer Agents, Anti-Cancer Agents in Medicinal Chemistry 2016; 16 (8) . https://dx.doi.org/10.2174/1871520616666160211124240
DOI https://dx.doi.org/10.2174/1871520616666160211124240 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
Call for Papers in Thematic Issues
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs
Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase ...read more
Role of natural compounds as anti anti-cancer agents
Cancer is considered the leading cause of worldwide mortality, accounting for nearly 10 million deaths in 2022. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy remains an important approach in treatment o f several types of cancers, even though ...read more
Signaling and enzymatic modulators in cancer treatment
Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Engineering of Plant Metabolism for Drug and Food
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Stem Cells and the Side Population Theory: A Critical Review
Current Tissue Engineering (Discontinued) Towards Characterization of the Human Urinary Peptidome
Combinatorial Chemistry & High Throughput Screening How to Inhibit Telomerase Activity for Cancer Therapy
Current Medicinal Chemistry - Anti-Cancer Agents Angiogenesis and Microvasculature in the Female Reproductive Organs: Physiological and Pathological Implications
Current Pharmaceutical Design Role of Renin-Angiotensin System in Inflammation, Immunity and Aging
Current Pharmaceutical Design Traumatic Brain Injury and Blood-Brain Barrier Cross-Talk
CNS & Neurological Disorders - Drug Targets Antimitotic Chalcones and Related Compounds as Inhibitors of Tubulin Assembly
Anti-Cancer Agents in Medicinal Chemistry Anti-Metastatics: An Overview of Drug Candidates in Current Pipelines
Current Pharmaceutical Design Editorial [Hot Topic Nanoparticulates for Improved Treatment of Severe Skin Diseases (Guest Editors: Eliana B. Souto, Aristoteles Rosmaninho and Tatiana Andreani)]
Current Nanoscience In vivo Optical Molecular Imaging of Cardiovascular Diseases: Long Road Ahead
Current Molecular Imaging (Discontinued) Oxidative Stress, Mitochondrial Abnormalities and Proteins Deposition: Multitarget Approaches in Alzheimer's Disease
Current Topics in Medicinal Chemistry Development and Current Status of Unconventional Platinum Anticancer Complexes
Mini-Reviews in Medicinal Chemistry Retraction Notice: Current Management of Vomiting After Tonsillectomy in Children
Current Drug Safety Small Activating RNAs as Promising Agents for Biotechnological Use
Current Pharmaceutical Biotechnology Roles of Casein Kinase I η and δ in Gastrointestinal Cancers: Potential New Screening Markers and Drug Targets
Current Cancer Therapy Reviews Performance of Feature Selection Methods
Current Genomics Design and Biological Evaluation of 3-Aryl-4-alkylpyrazol-5-amines Based on the Target Fishing
Current Computer-Aided Drug Design Potential Therapeutic Properties of Natural Products Through the Expression of Heme Oxygenase-1
Mini-Reviews in Organic Chemistry New Derivatives of GnRH as Potential Anticancer Therapeutic Agents
Current Medicinal Chemistry