Objective: The current study was planned to analyze the effects of the aqueous extract of
Cynodon dactylon (AECD) in a rat model of Streptozotocin (STZ) induced-diabetes and nitric oxide
Materials and Methods: Diabetes was induced by a single dose of STZ (55 mg/kg, i.p., in 0.1M citrate
buffer, pH 4.5). To induce the NO-deficient hypertension, rats were treated with the Nitric Oxide
synthase inhibitor- NG-nitro-l-arginine methyl ester; L-NAME (0.5 mg/ml), p.o. for 4 weeks. The effects observed after 28
days treatment with aq. extract of Cynodon dactylon 200 mg⁄ kg per day were evaluated in diabetic–hypertensive rats. In
all groups, body weight of animals was measured weekly throughout the study (28 days). Blood glucose level and total
cholesterol level were measured at day 0 after induction of diabetes and at day 28. Arterial blood pressure of all the
groups were measured at day 14 and day 28 by tail cuff method. At the end of experiment, Serum glutamic oxaloacetic
transaminase (SGOT) level in all groups was measured.
Results: A decrease in body weight was observed in the case of STZ diabetic, L-NAME and D+L-NAME control groups
whereas no loss in the weight of animal was observed in the group treated with the aqueous extract of C. dactylon. The
study showed that a) aqueous leaf extract of Cynodon dactylon prevented attenuation of the blood glucose and total cholesterol
in all the groups; b) significant decrease in Mean Arterial Blood Pressure (MABP) and c) decrease in SGOT level.
Conclusion: The traditional use of Cynodon dactylon for the treatment of diabetes and arterial hypertension is supported
by the findings of present study, and indicate that it may have a beneficial effect in patients with co-existing diabetic hypertension.