Calcitonin gene-related peptide (CGRP) is extensively distributed throughout the central
and peripheral nervous systems and has been shown to be a 37 amino acid multifunctional neuropeptide
involved in a wide range of physiological and pathological processes. Recently, there is increasing
evidence suggesting that CGRP also exists in non-nerve cells, such as epithelial cells, endothelial
cells, endothelial progenitor cells (EPCs), T lymphocytes, B lymphocytes, peripheral blood mononuclear
cells (PBMCs), and adipocytes. The existence of CGRP in non-neural tissue is of great importance
to the regulation of multiple physiological and pathological processes via different pathways,
especially through an autocrine/paracrine mode. This review integrates evidence from recent developments and aims to
provide novel insights into non-neural sources of CGRP and its effects on physiological and pathological processes.
Keywords: Adipocytes, CGRP, endothelial cells, EPCs, epithelial cells, hepatocytes, immunocytes.
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