Dextran-based Nanocarriers for Delivery of Bioactives

Author(s): Rania A.H. Ishak, Rihab Osman, Gehanne A.S. Awad.

Journal Name: Current Pharmaceutical Design

Volume 22 , Issue 22 , 2016

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Abstract:

Background: Dextran (DX) is a natural polysaccharide produced in the laboratory by fermentation of sucrose under the effect of the enzyme DX sucrase (1,6-α-D-glucan-α- glucosyltransferase). After harvesting and purification DX is subjected to cracking and separation to obtain the desired molecular weight. Methods: The hydroxyl groups present in DX offer many sites for derivatization allowing the production of functionalized glycoconjugates biocompatible compound. DX and its derivatives are getting increased attention for use in core decoration or as carriers in novel drug delivery systems. This includes, among others, ion-pairing, self-aggregate, protein and drug conjugates. DX carriers and camouflaged particles will be dealt with in this review to give emphasis on the great versatility of this natural biocompatible polysaccharide. Conclusion: With the continuous development in the area of drug delivery, we believe that the unique properties of this versatile nanocarrier platform will elect it as one of the cornerstones of safe nanodelivery systems.

Keywords: Dextran, amphiphiles, conjugates, ion pairing, ionic complexation, layer-by-layer, stabilizer, self-assembly.

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Article Details

VOLUME: 22
ISSUE: 22
Year: 2016
Page: [3411 - 3428]
Pages: 18
DOI: 10.2174/1381612822666160209152329
Price: $58

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