Acidity-Activated Shielding Strategies of Cationic Gene Delivery for Cancer Therapy

Author(s): Jialiang Xia , Zongcai Feng , Hongyan Yang , Sanqing Lin , Bing Han .

Journal Name: Current Pharmaceutical Biotechnology

Volume 17 , Issue 3 , 2016

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Abstract:

Cationic gene vectors increased attractive for gene therapy. However, unstable systemic circulation due to the interaction of gene delivery system with blood cells limited the further application. Therefore, pH sensitive shielding systems were exploited, by which, the positive surface charge density of polyplexes was reduced, circulation time was improved and pH-triggered targeting delivery was promised. This mini review mainly focuses on the development of solid tumors pH environment activated shielding systems for cationic gene vectors. This shielding strategy shows great potential for enhancing efficient gene transporting and achieving better therapeutic effects in acidic tumor treatment.

Keywords: Cancer therapy, gene delivery, acidity responsive, shielding strategy.

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Article Details

VOLUME: 17
ISSUE: 3
Year: 2016
Page: [256 - 262]
Pages: 7
DOI: 10.2174/138920101703160206144220
Price: $58

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