The treatment with antiepileptic drugs (AEDs), in particular conventional drugs, induces an
increased risk of fractures in women and in epileptic patients in treatment with AEDs for more than
12 years. A supplementation with calcium and vitamin D is suggested in patients chronically treated
with some AEDs and there are recommendations to do so. The lack of significant conclusive evidence
about the effects of conventional and newer AEDs on bone metabolism needs for more clinical studies
in order to perform an appropriate use of calcium and vitamin D supplementation in young and ederly
Keywords: AEDs, bone metabolism, calcium, vitamin D, women.
Rights & PermissionsPrintExport