Thiophene Scaffold as Prospective Central Nervous System Agent: A Review

Author(s): Aakash Deep, Balasubramanian Narasimhan, Swati Aggarwal, Dhirender Kaushik, Arun K. Sharma.

Journal Name: Central Nervous System Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Central Nervous System Agents)

Volume 16 , Issue 2 , 2016

Become EABM
Become Reviewer

Graphical Abstract:


Background: Heterocyclic compounds are extensively dispersed in nature and are vital for life. Various investigational approaches towards Structural Activity Relationship that focus upon the exploration of optimized candidates have become vastly important.

Method: Literature studies tell that for a series of compounds that are imperative in industrial and medicinal chemistry, thiophene acts as parent. Among various classes of heterocyclic compounds that have potential central nervous system activity, thiophene is the most important one. In the largely escalating chemical world of heterocyclic compounds showing potential pharmacological character, thiophene nucleus has been recognized as the budding entity.

Result: Seventeen Papers were included in this review article to define the central nervous system potential of thiophene. This review article enlightens the rationalized use and scope of thiophene scaffold as novel central nervous system activity such as anticonvulsant, acetylcholinesterase inhibitor, cyclin-dependent kinase 5 (cdk5/p25) inhibitors, CNS depressant, capability to block norepinephrine, serotonin and dopamine reuptake by their respective transporters etc.

Conclusion: The Finding of this review confirm the importance of thiophene scaffold as potential central nervous system agents. From this outcome, ideas for future molecular modifications leading to the novel derivatives with better constructive pharmacological potential may be derived.

Keywords: Anticonvulsant, acetylcholinesterase inhibitor, Thiophene and its derivatives.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2016
Page: [158 - 164]
Pages: 7
DOI: 10.2174/1871524916666160204114424
Price: $58

Article Metrics

PDF: 29