Background: Heterocyclic compounds are extensively dispersed in nature and are vital for
life. Various investigational approaches towards Structural Activity Relationship that focus upon the
exploration of optimized candidates have become vastly important.
Method: Literature studies tell that for a series of compounds that are imperative in industrial and medicinal
chemistry, thiophene acts as parent. Among various classes of heterocyclic compounds that
have potential central nervous system activity, thiophene is the most important one. In the largely escalating chemical
world of heterocyclic compounds showing potential pharmacological character, thiophene nucleus has been recognized as
the budding entity.
Result: Seventeen Papers were included in this review article to define the central nervous system potential of thiophene.
This review article enlightens the rationalized use and scope of thiophene scaffold as novel central nervous system activity
such as anticonvulsant, acetylcholinesterase inhibitor, cyclin-dependent kinase 5 (cdk5/p25) inhibitors, CNS depressant,
capability to block norepinephrine, serotonin and dopamine reuptake by their respective transporters etc.
Conclusion: The Finding of this review confirm the importance of thiophene scaffold as potential central nervous system
agents. From this outcome, ideas for future molecular modifications leading to the novel derivatives with better constructive
pharmacological potential may be derived.