Malignant Pleural Mesothelioma: Present Status and Future Directions

Malignant pleural mesothelioma is a life-threatening neoplasm of the mesothelium, the layer of tissue that covers many organs in the human body. The incidence of this type of neoplasm is gradually ...
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Novel Genetic Therapies in Malignant Pleural Mesothelioma

Pp. 335-346 (12)

Assunta De Rienzo and Raphael Bueno

Abstract

Malignant pleural mesothelioma (MPM) is an uncommon, but lethal malignancy resistant to most current therapies. It represents a good field of investigation for gene therapy because the disease remains confined for a long time during its growth and the neoplasm is quite accessible through the chest wall. Translational mechanisms for the treatment of this disease are emerging from the novel high-throughput molecular techniques, but a therapeutic gene capable of inhibiting the disease progression through specific gene therapy has not yet been identified. Several trials on gene therapy have been conducted in the last two decades showing safety but limited efficacy. Recent progress in the field has provided optimism for successful molecular strategies in the future.

Keywords:

Mesothelioma, gene therapy, adenovirus, high-throughput techniques.

Affiliation:

Thoracic Surgery, Oncology laboratory and International Mesothelioma Program, Division of Thoracic Surgery, Brigham and Womens Hospital 75 Francis Street, Boston, MA 02115, USA.