Malignant Pleural Mesothelioma: Present Status and Future Directions

Malignant pleural mesothelioma is a life-threatening neoplasm of the mesothelium, the layer of tissue that covers many organs in the human body. The incidence of this type of neoplasm is gradually ...
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Genetics of Malignant Pleural Mesothelioma

Pp. 155-168 (14)

Dean A. Fennell, Annabel J. Sharkey and Sara Busacca

Abstract

Malignant pleural mesotheliomais characterised by a large range of complex genetic alterations and peculiarof this disease. The mesothelioma genome contains extensive copy number alterations and aneuploidy which may correlate with response to treatment and survival. The genetics of mesothelioma has increased considerably over the last decade with major advances in whole genome and next generation sequencing. The knowledge of the genomics of mesothelioma is essential for identifying new, effective personalised therapeutic approaches therapies for improving clinical outcomes in patients with mesothelioma.

Keywords:

BAP1, CDKN2A/ARF, chromosomal loss, comparative genomic hybridisation, Genetics, hypermethylation, NF2/Merlin.

Affiliation:

Cancer Research UK Leicester Centre, University of Leicester, and Laboratory 411, 4th Floor, Hodgkin Building, Leicester, United Kingdom.