Retinal adhesion mechanisms in mammals are quite complex and multifactorial in nature.
To date, these mechanisms are incompletely understood due to a variety of chemical, physical, and physiological forces
impinging upon retinal tissue: retinal pigment epithelium, nearby tissues as sclera and vitreous, the subretinal space, and
the highly complex interphotoreceptor matrix that fills subretinal space. The adhesion of the retina to the choroid, rather
than anatomical, is a dynamic process, as the retina detaches a few minutes after life ceases. The adhesion mechanisms
described in the literature, such as intraocular pressure and the oncotic pressure of the choroid that seems to push the
retina towards the choroid, the delicate anatomical relationships between the rod and cone photoreceptors, the retinal
pigment epithelium, the existence of a complex material called interphotoreceptor matrix, as well as other metabolic and
structural factors, still cannot explain the remarkable features observed in the adhesion mechanisms between the
photoreceptor layer and retinal pigment epithelium cells. The unexpected intrinsic property of melanin to absorb light
energy and transform it into chemically based free energy can explain normal adhesion of the sensory retina to the
pigment epithelium. In this article, we explore and highlight this explanation, which states that it is definitely able to
provide a new treatment avenue against devastating neurodegenerative properties.