Abstract
Herein, we describe a simple, four-step process for the preparation of 1,2,3-triazino[1,6- a]quinazolin-13-ones. This method involves ring-opening, quinazoline-forming condensation, reduction, diazotization accompanied by rapid intramolecular cyclization in the last step afforded the desired products with structurally complex heterocyclic core in excellent to high yields.
Keywords: N-N bond forming, Heterocyclization, Triazine, Quinazoline, Diazonium, Isatoic anhydride.
Combinatorial Chemistry & High Throughput Screening
Title:An Efficient Four-Step Approach Toward Fused Triazino[1,6-a] Quinazolines
Volume: 19 Issue: 3
Author(s): Mohammad Hosein Sayahi, Shirin Baghersaei, Fereshteh Goli, Setareh Moghimi, Mohammad Mahdavi, Loghman Firoozpour, Abbas Shafiee and Alireza Foroumadi
Affiliation:
Keywords: N-N bond forming, Heterocyclization, Triazine, Quinazoline, Diazonium, Isatoic anhydride.
Abstract: Herein, we describe a simple, four-step process for the preparation of 1,2,3-triazino[1,6- a]quinazolin-13-ones. This method involves ring-opening, quinazoline-forming condensation, reduction, diazotization accompanied by rapid intramolecular cyclization in the last step afforded the desired products with structurally complex heterocyclic core in excellent to high yields.
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Sayahi Hosein Mohammad, Baghersaei Shirin, Goli Fereshteh, Moghimi Setareh, Mahdavi Mohammad, Firoozpour Loghman, Shafiee Abbas and Foroumadi Alireza, An Efficient Four-Step Approach Toward Fused Triazino[1,6-a] Quinazolines, Combinatorial Chemistry & High Throughput Screening 2016; 19 (3) . https://dx.doi.org/10.2174/1386207319666160202120802
DOI https://dx.doi.org/10.2174/1386207319666160202120802 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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