Regioisomerically pure 5(6)-substituted rhodamine is an outstanding molecular platform for functional
probes and a very useful material for fluorescent labels. However, 5(6)-substituted rhodamine is difficult to be synthesized
by general methods, which limits the application of the dye. This review highlights the progress regarding
the methods for the synthesis and separation of regioisomerically pure 5(6)-substituted rhodamine, which are categorized
by the four different protocols for acquiring 5(6)-substituted rhodamine. The advantages and disadvantages
of each protocol are also discussed.
Keywords: Regioisomerically pure, substituted rhodamine, separation, synthesis.
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