Introduction: Nutraceutical is a term applied for a plethora of products ranging from isolated nutrients, herbal
products to dietary supplements and recently, the interest for a nutraceutical approach to lipid and metabolic disorders is
growing. Patients with metabolic conditions seem to appreciate a therapeutic management that does not involve drug
treatment, particularly for the side effects due to statins, a class of drug used for lipid disorders. Statins directly induce
skeletal muscle injury and in the elderly patients, under polytherapy treatments, this risk relies to an increase in adverse
drug reactions due to drug interactions.
Case Description: Herein we report a 70-year-old woman under polytherapy who developed rhabdomyolysis after starting
the administration of a dietary supplement containing monacolin K. Using the Drug Interaction Probability Scale, we
postulated that rhabdomyolysis was possibly related to a drug interaction between sertraline, rosuvastatin and monacolin
K. These treatments were discontinued leading to a remission of both clinical symptoms and biochemical parameters.
Conclusion: This case report highlights how pharmacological treatment must be periodically reassessed, since elderly
people could take drugs by themselves when they donot need.