Human mesenchymal stem cells (hMSCs) are multipotent non-hematopoietic precursor
cells with the ability to differentiate into several tissue types. The use of hMSCs has gained significant
importance in cancer therapies as well as a large number of degenerative disease therapies due to their
homing abilities. However, these cells may undergo spontaneous transformation leading to them bypassing
naturally built-in cell controls that could lead to senescence and carcinogenesis. Therefore, although
MSCs have great potential for cancer therapy, they also risk the development of cancer, which
provides them with double-faced characteristics for both cancer development and therapy. The potential
use of hMSCs in therapeutics from the aspect of in vitro expansion of hMSCs and telomere dynamic is discussed.
Keywords: Cancer therapy, differentiation, mesenchymal stem cells, neoplastic transformation, telomere.
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