Double-Faced Role of Human Mesenchymal Stem Cells and their Role/Challenges in Cancer Therapy

Author(s): Nedime Serakinci, Rasime Kalkan, Pinar Tulay.

Journal Name: Current Stem Cell Research & Therapy

Volume 11 , Issue 4 , 2016

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Abstract:

Human mesenchymal stem cells (hMSCs) are multipotent non-hematopoietic precursor cells with the ability to differentiate into several tissue types. The use of hMSCs has gained significant importance in cancer therapies as well as a large number of degenerative disease therapies due to their homing abilities. However, these cells may undergo spontaneous transformation leading to them bypassing naturally built-in cell controls that could lead to senescence and carcinogenesis. Therefore, although MSCs have great potential for cancer therapy, they also risk the development of cancer, which provides them with double-faced characteristics for both cancer development and therapy. The potential use of hMSCs in therapeutics from the aspect of in vitro expansion of hMSCs and telomere dynamic is discussed.

Keywords: Cancer therapy, differentiation, mesenchymal stem cells, neoplastic transformation, telomere.

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Article Details

VOLUME: 11
ISSUE: 4
Year: 2016
Page: [343 - 351]
Pages: 9
DOI: 10.2174/1574888X11666160201115733
Price: $58

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