Synthesis and Biological Evaluation of Macamides Derivatives as Potent Inhibitors of Breast Cancer Cell MCF-7

Author(s): Xiao Xia Liang, Cheng Xiong, Min He, Changliang He, Zhongqiong Yin.

Journal Name: Letters in Drug Design & Discovery

Volume 13 , Issue 6 , 2016

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Abstract:

A series of macamides (1-4) and their synthetic analogs (5-14) were synthesized and evaluated for in vitro inhibitory activities against breast cancer cell MCF-7. The results of bioactive assay showed that two of the macamides (compound 1 and 4) and one synthetic analog (compound 5) displayed comparable inhibitory activities against MCF-7 cell line, with IC50 values of 29.6, 36.2 and 27.2 µM, respectively.

Keywords: Macamides derivatives, inhibitory activity, MCF-7.

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Article Details

VOLUME: 13
ISSUE: 6
Year: 2016
Page: [489 - 494]
Pages: 6
DOI: 10.2174/1570180813888160201100814
Price: $58

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