Analgesic and CNS Depressant Activities of Sea Anemone Heteractis aurora Nematocyst Toxin

Author(s): Sengapillai Thangaraj, Subramanian Bragadeeswaran, Natarajah Srikumaran, Anbukkarasu Suguna.

Journal Name: Central Nervous System Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Central Nervous System Agents)

Volume 16 , Issue 3 , 2016

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Abstract:

Marine organisms are the excellent sources for biologically active compounds. Cnidarian venoms are potentially valuable materials used for biomedical research and drug development. The present work was carried out to analyse haemolytic, analgesic and CNS depressant activity of sea anemone Heteractis aurora. In haemolytic assay, among the five different RBC blood cells, the chicken blood exhibited maximum hemolytic activity of 64 Hemolytic Unit (HU). The maximum Analgesic Ratio (AR) of 5 recorded at 15 and 30 min interval and minimum was recorded after 45, 60 and 120 min time intervals. In jumping response activity, the maximum of 5 AR recorded at 15, 30 & 45 min and minimum was recorded at 90 & 120 min time intervals. The maximum decrease of depressant activity of 45.07% was determined in CNS depressant activity. Anti-inflammatory activity showed significant inhibition by crude extract of Heteractis aurora.

Keywords: Analgesic activity, CNS depressant activity, Heteractis aurora, Haemolytic activity, Sea anemone.

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Article Details

VOLUME: 16
ISSUE: 3
Year: 2016
Page: [167 - 172]
Pages: 6
DOI: 10.2174/1871524916666160129101049
Price: $58

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