Abstract
Marine organisms are the excellent sources for biologically active compounds. Cnidarian venoms are potentially valuable materials used for biomedical research and drug development. The present work was carried out to analyse haemolytic, analgesic and CNS depressant activity of sea anemone Heteractis aurora. In haemolytic assay, among the five different RBC blood cells, the chicken blood exhibited maximum hemolytic activity of 64 Hemolytic Unit (HU). The maximum Analgesic Ratio (AR) of 5 recorded at 15 and 30 min interval and minimum was recorded after 45, 60 and 120 min time intervals. In jumping response activity, the maximum of 5 AR recorded at 15, 30 & 45 min and minimum was recorded at 90 & 120 min time intervals. The maximum decrease of depressant activity of 45.07% was determined in CNS depressant activity. Anti-inflammatory activity showed significant inhibition by crude extract of Heteractis aurora.
Keywords: Analgesic activity, CNS depressant activity, Heteractis aurora, Haemolytic activity, Sea anemone.
Central Nervous System Agents in Medicinal Chemistry
Title:Analgesic and CNS Depressant Activities of Sea Anemone Heteractis aurora Nematocyst Toxin
Volume: 16 Issue: 3
Author(s): Sengapillai Thangaraj, Subramanian Bragadeeswaran, Natarajah Srikumaran and Anbukkarasu Suguna
Affiliation:
Keywords: Analgesic activity, CNS depressant activity, Heteractis aurora, Haemolytic activity, Sea anemone.
Abstract: Marine organisms are the excellent sources for biologically active compounds. Cnidarian venoms are potentially valuable materials used for biomedical research and drug development. The present work was carried out to analyse haemolytic, analgesic and CNS depressant activity of sea anemone Heteractis aurora. In haemolytic assay, among the five different RBC blood cells, the chicken blood exhibited maximum hemolytic activity of 64 Hemolytic Unit (HU). The maximum Analgesic Ratio (AR) of 5 recorded at 15 and 30 min interval and minimum was recorded after 45, 60 and 120 min time intervals. In jumping response activity, the maximum of 5 AR recorded at 15, 30 & 45 min and minimum was recorded at 90 & 120 min time intervals. The maximum decrease of depressant activity of 45.07% was determined in CNS depressant activity. Anti-inflammatory activity showed significant inhibition by crude extract of Heteractis aurora.
Export Options
About this article
Cite this article as:
Thangaraj Sengapillai, Bragadeeswaran Subramanian, Srikumaran Natarajah and Suguna Anbukkarasu, Analgesic and CNS Depressant Activities of Sea Anemone Heteractis aurora Nematocyst Toxin, Central Nervous System Agents in Medicinal Chemistry 2016; 16 (3) . https://dx.doi.org/10.2174/1871524916666160129101049
DOI https://dx.doi.org/10.2174/1871524916666160129101049 |
Print ISSN 1871-5249 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6166 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Protective Roles and Molecular Mechanisms of Troxerutin (Vitamin P4) for the Treatment of Chronic Diseases: A Mechanistic Review
Current Neuropharmacology A Probable Topiramate-induced Limbs Paraesthesia and Rigid Fingers Flexion
Current Drug Safety Uteroplacental Circulation and Fetal Vascular Function and Development
Current Vascular Pharmacology Association between Thiopurines Use and Pregnancy Outcomes in Female Patients with Inflammatory Bowel Disease: A Meta-Analysis
Current Pharmaceutical Design Prion Disease: Chemotherapeutic Strategies
Infectious Disorders - Drug Targets Single Chemical Entity Legal Highs: Assessing the Risk for Long Term Harm
Current Drug Abuse Reviews Brain Arrhythmias Induced by Amyloid Beta and Inflammation: Involvement in Alzheimer’s Disease and Other Inflammation-related Pathologies
Current Alzheimer Research Improvement of Abiotic Stress Tolerance of Crops Via Enhancement of their Antioxidant Capacity
Current Chemical Biology Overview of the Recent Advances in Pathophysiology and Treatment for Autism
CNS & Neurological Disorders - Drug Targets C5a, a Therapeutic Target in Sepsis
Recent Patents on Anti-Infective Drug Discovery Nociceptin/Orphanin FQ Peptide Receptors: Pharmacology and Clinical Implications
Current Drug Targets Uridine Function in the Central Nervous System
Current Topics in Medicinal Chemistry Identifying Patterns in Signs and Symptoms Preceding the Clinical Diagnosis of Alzheimer’s Disease: Retrospective Medical Record Review Study and a Nested Case-control Design
Current Alzheimer Research Reversal of Cardiac Iron Loading and Dysfunction in Thalassemic Mice by Curcuminoids
Medicinal Chemistry Neurotransmitter Imaging: Basic Concepts and Future Perspectives
Current Medical Imaging Drug Metabolism and Individualized Medicine
Current Drug Metabolism Survival Factors from Activated Accessory Cells and their Role in Triggering Autoimmune Diseases
Current Medicinal Chemistry Momordica balsamina: A Medicinal and Neutraceutical Plant for Health Care Management
Current Pharmaceutical Biotechnology Acknowledgements to Reviewers
Current Neuropharmacology Nanomedicine Strategies for Sustained, Controlled and Targeted Treatment of Alzheimer’s Disease
Mini-Reviews in Medicinal Chemistry