The Cholinergic Potential, the Vagus Nerve and Challenges in Treatment of Traumatic Brain Injury

Author(s): Victor V. Uteshev , Olli Tenovuo , Nikhil Gaidhani .

Journal Name: Current Pharmaceutical Design

Volume 22 , Issue 14 , 2016

Abstract:

Existing treatments of traumatic brain injury (TBI) have failed to reverse tremendous losses in productivity, independence and overall quality of life among TBI victims and therefore, cannot be viewed as sufficient. Although there is no shortage of promising basic concepts that may translate to efficacious therapies after TBI, the accumulated knowledge has yet to deliver treatments that adequately meet clinical and social demands. In this article, we discuss novel concepts, recent advances and accompanying challenges in developing cholinergic and related therapies after TBI.

Keywords: Trauma, brain, injury, cholinergic, nicotinic, acetylcholine, vagus, vagal, stimulation, inflammatory, immune.

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Article Details

VOLUME: 22
ISSUE: 14
Year: 2016
Page: [2083 - 2092]
Pages: 10
DOI: 10.2174/1381612822666160127111630
Price: $58

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