The field of medicine is rapidly moving towards the development of personalized
treatments and non-invasive tools to achieve a more predictable and optimal
tissue regeneration. In this sense, the goal of periodontal healing is to arrest disease
progression and functionally regenerate all the tissues that comprise the periodontium.
The latter implies a well-orchestrated interaction among oral cells, growth factors and
extracellular matrix. Although several procedures are performed in an attempt to regenerate lost periodontal tissue, outcomes
are not always predictable. Growth factors represent a class of biologically active polypeptides that have a critical
role in the healing process. Their use provides a new paradigm to understand the regenerative medicine. The use of platelet-
rich plasma (PRP) products as a local source and delivery system of autologous growth factors has emerged recently.
Among them, PRGF stands for its remarkable stimulatory effect on oral tissue regeneration, making it a very safe and
successful tool with a great value in Dentistry.
Keywords: Growth factors, platelet rich plasma, gingival fibroblast, periodontal ligament, alveolar osteoblasts and implant
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