This mini-review describes the interest in synthetic methodologies using
KF/Al2O3 in various organic reactions focusing on the preparation of organochalcogen
compounds. The use of this environmentally friendly reagent as an efficient and versatile
heterogeneous base to promote the addition of chalcogen nucleophiles to alkynes
and α,β-unsaturated compounds has increased in the last decade. Besides addition reactions,
substitution, cross-coupling, condensation, cyclization, multicomponent and
oxidation reactions and others are among the plethora of methods to prepare organic
compounds containing selenium, tellurium or sulfur. In a general way, the reactions using KF/Al2O3 as the base are
cleaner and faster than those using homogeneous basic catalysis. The solid supported KF is suitable to reactions under
solvent-free conditions accelerated by irradiation with microwaves and can be easily recycled and reused in successive reactions,
making it an excellent choice for the green synthesis of organochalcogen compounds.
Keywords: Alumina, green chemistry, KF/Al2O3, selenium, sulfur, tellurium.
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