Bioresorbable Scaffolds for Atheroregression: Understanding of Transient Scaffolding

Author(s): Alexander N. Kharlamov.

Journal Name: Current Cardiology Reviews

Volume 12 , Issue 1 , 2016

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Abstract:

This review focuses on the clinical and biological features of the bioresorbable scaffolds in interventional cardiology highlighting scientific achievements and challenges of the transient scaffolding with Absorb BVS. Special attention is granted to the vascular biology pathways which, involved in the resorption of scaffold, artery remodeling and mechanisms of Glagovian atheroregression setting the stage for subsequent clinical applications. Twenty five years ago Glagov described the phenomenon of limited external elastic membrane enlargement in response to an increase in plaque burden. We believe this threshold becomes the target for development of strategies that reverse atherosclerosis, and particularly transient scaffolding has a potential to be a tool to ultimately conquer atherosclerosis.

Keywords: Artery remodeling, atheroregression, bioresorption, bioresorbable scaffold, glagov phenomenon, stenting.

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Article Details

VOLUME: 12
ISSUE: 1
Year: 2016
Page: [66 - 82]
Pages: 17
DOI: 10.2174/1573403X1201160126125853
Price: $58

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