Novel Biphenyl Derivatives with α-Aminophosphonate Moiety: Design, Synthesis and Antivirus Activity

Title:Novel Biphenyl Derivatives with α-Aminophosphonate Moiety: Design, Synthesis and Antivirus Activity

Volume: 13 Issue: 7

Author(s): Guo-Ping Zhang and Min Liu

Affiliation:

Keywords: Biphenyl derivatives, α-aminophosphonate, antiviral activity, synthesis.

Abstract: A series of novel biphenyl derivatives with -aminophosphonate moiety was designed and successively synthesized through Suzuki-Miyaura and Kabachnik-Fields reaction. The structures of the target compounds were confirmed by ¹H NMR, ¹³C NMR, ³¹P NMR, IR and H MRS. The antiviral activity against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV) indicated that most of the target compounds exhibited certain anti-TMV and good anti-CMV activities, respectively, in which compound 4d displayed higher anti-TMV activity and compound 4s exhibited higher anti-CMV activity than the commercial agent Ningnanmycin.

Cite this article as:

Zhang Guo-Ping and Liu Min, Novel Biphenyl Derivatives with α-Aminophosphonate Moiety: Design, Synthesis and Antivirus Activity, Letters in Drug Design & Discovery 2016; 13 (7) . https://dx.doi.org/10.2174/1570180813666160125222813