Energy intake and expenditure are regulated by a complex network of neurochemical systems. The results
of numerous studies have provided information about receptors involved, the sites of action within the brain
and interactions between various systems, including opioid and cannabinoid, in regulation of energy balance. This
review summarizes our present knowledge on the opioid and cannabinoid system appetite and satiety pathways. The involvement of the
three main types of opioid receptors (MOR, DOR and KOR) and CB1 cannabinoid receptor, as well as the endogenous ligands of these
receptors in food intake is documented. Finally, the use of opioid-cannabinoid system interactions as a new approach in the search for the
next generation therapeutics controlling food intake disorders is discussed.
Keywords: Opioid and cannabinoid receptors, obesity, anorexia nervosa, bulimia nervosa, orexigenic and anorexigenic peptides.
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