Prostate cancer (PCa) is a leading cause of death in men worldwide. The main reason for
the progression of prostate cancer is identified as over activation of androgen receptor (AR) through
androgens. Its development can be diagnosed by monitoring the prostate specific antigen (PSA).
Treatment of PCa includes prostatectomy, radiotherapy, and chemotherapy, among them chemotherapy
is normally employed in early and advanced prostate cancer. Chemotherapy mainly includes two
classes of drugs which are steroidal and non-steroidal antiandrogens. The non-steroidal classes of
compounds are preferred over steroidal because they are relatively safe, cost effective and diverse.
Non-steroidal drugs are commonly used for the treatment of PCa, however these drugs are associated with serious side
effects and acquired resistance. So researchers are working in the direction to develop better analogue which can address
the issue related to resistant type of prostate cancer. This review discusses the advancement in the non-steroidal
antiandrogens which offers a better potential in the treatment of prostate cancer.
Keywords: Androgen receptor, Antiandrogen, Chemotherapy, Non-steroidal, Prostate cancer, Testosterone.
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