Neuroprotective Role of Nanoparticles Against Alzheimer's Disease

Author(s): Magisetty Obulesu , Magisetty Jhansilakshmi .

Journal Name: Current Drug Metabolism

Volume 17 , Issue 2 , 2016


Abstract:

Background: Alzheimer's disease (AD) is a devastative neurodegenerative disorder with a complex etiology. Despite numerous novel nanotechnology methods targeted against cancer and neurodegenerative diseases such as AD in the past decade, several challenges impeded their success.

Objective: We ventured to circumvent these challenges by synthesizing redox nanoparticles (RNP) such as Nitroxide radical, 2,2,6,6 tetramethylpiperidinyl-N-oxyl (TEMPO). Piperine in association with RNP successfully scavenges reactive oxygen species (ROS). Our studies have also shown that the piperine associated with RNP confers enhanced protection against AD in vitro.

Conclusion: This review summarizes our recent findings on the protective roles of redox nanoparticles both in vitro and in vivo. In addition, vital role of nanoparticles employed to encapsulate natural compounds such as curcumin and metal chelators has been summarized. We warrant further studies in animal models using these protective nanoparticles.

Keywords: Alzheimer’s disease, curcumin, metal chelators, Redox nanoparticles.

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Article Details

VOLUME: 17
ISSUE: 2
Year: 2016
Page: [142 - 149]
Pages: 8
DOI: 10.2174/138920021702160114160341
Price: $58

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