Background: Advances in nanotechnology have enabled new strategies for transport, controlled
deliver, preservation and increases in stability of degradable biomolecules. Nanoparticles have
been developed for alimentary porpoises, using a great diversity of raw materials. Poly(lactide-coglicolide)
acid (PLGA) a biodegradable polyester, has been used extensively as a controlled delivery
platform for a great variety of biomolecules and drugs.
Methods: Extracts from Zea mays and Phaseolus vulgaris were obtained and characterized, PLGA
nanoparticles were prepared by emulsion-solvent evaporation method and loaded with antioxidant extracts. Finally, antioxidant-
loaded nanoparticles were incorporated into a film-forming solution and antioxidant release were tested in a meal
Results: Antioxidant-loaded nanoparticles (300 – 500 nm), were prepared with adequate stability. Encapsulation efficiency
showed a mean value of 67.4 % for bean and 41 % for corn extracts. IR-FT provided information about nanoparticle
formation and encapsulation. Kinetic release of antioxidants demonstrate a prolonged delivery of phenolic compounds
from nanoparticles (< 60 h). In situ test showed the functionality of PLGA-NP as food additive for controlled release of
Conclusion: Antioxidant encapsulation and loading efficiency in PLGA matrix, produce a stable nanostructure with adequate
characteristics for sustained and controlled release, with a great variety of possible applications as an alimentary additive.