The recent progress on controlled-release drug delivery systems with cyclodextrins as
functional groups and their applications in nanomedicine are reviewed. As one of the most famous
supramolecular host candidates, cyclodextrins with small guest molecules are extensively
employed in controlled-release drug delivery systems in nanomedicine fields. The host-guest
interactions between cyclodextrins and the guest molecules can be triggered by various stimulations,
including temperature, light, pH, etc. In this review, we will focus on the cyclodextrinbased
controlled-release systems mainly triggered by light. The comparison between photoresponsive
and other controlled-release drug delivery systems is also discussed.
Keywords: Photochemistry, cyclodextrin, stimuli-responsive, drug delivery, controlled-release, polymer, mesoporous silica, hydrogel.
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