Thrombosis is a well known phenomenon among physicians since antiquity. A variety of peculiar
agents, such as leeches and bark, were used to prevent it. Hirudin was used during the 19th century. The next eon,
heparin, strepokinase, urokinase, TPA, dicumarol, warfarin, aspirin, ticlopidine, Clopidogrel, SSHA and SP54 provoked
huge advances in anticoagulation. During 21st century with the use of fondaparinux, dabigatran, rivaroxaban
and Ticagrelor antithrombotic prevention and therapeutic interaction entered an era of medical challenges. Although the risk after a
thrombotic episode is now highly reduced, blood clots still present damaging or even lethal consequences in human organisms and further
research is strongly recommended.