Historical Hallmarks of Anticoagulation and Antiplatelet Agents

Author(s): Gregory Tsoucalas , Jacques Chevallier , Marianna Karamanou , Theodoros Papaioannou , Markos Sgantzos , George Androutsos .

Journal Name: Current Pharmaceutical Design

Volume 22 , Issue 13 , 2016

Abstract:

Thrombosis is a well known phenomenon among physicians since antiquity. A variety of peculiar agents, such as leeches and bark, were used to prevent it. Hirudin was used during the 19th century. The next eon, heparin, strepokinase, urokinase, TPA, dicumarol, warfarin, aspirin, ticlopidine, Clopidogrel, SSHA and SP54 provoked huge advances in anticoagulation. During 21st century with the use of fondaparinux, dabigatran, rivaroxaban and Ticagrelor antithrombotic prevention and therapeutic interaction entered an era of medical challenges. Although the risk after a thrombotic episode is now highly reduced, blood clots still present damaging or even lethal consequences in human organisms and further research is strongly recommended.

Keywords: Anticoagulants, antiplatelets, thrombosis, history of medicine.

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Article Details

VOLUME: 22
ISSUE: 13
Year: 2016
Page: [1857 - 1861]
Pages: 5
DOI: 10.2174/1381612822666160111124615
Price: $58

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