Mass spectrometry (LC-MS or LC-MS/MS) appears in all phases of drug discovery and
drug development areas. Starting with the screening and identification of a therapeutic agent and further
measuring its in vivo and in vitro properties include: absorption, distribution, metabolism, excretion
and toxicity (ADMET) and also pharmacokinetic (PK) and pharmacodynamic (PD) quantitative
parameters of drug candidate. Mass spectrometry also serves as a necessary tool also to confirm purity
and stability of analyzed new chemical entities (NCEs)/new molecular entities (NMEs) as well as for
the analysis of degradation products from the synthesis and following on every stages of drug discovery.
Keywords: Mass spectrometry, LC-MS, drug discovery, drug development, ADMET.
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