The Current Use of Mass Spectrometry in Combination with Other Separation Techniques in Drug Discovery Arena

Author(s): Piotr Kawczak, Tomasz Baczek.

Journal Name: Medicinal Chemistry

Volume 12 , Issue 5 , 2016

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Abstract:

Mass spectrometry (LC-MS or LC-MS/MS) appears in all phases of drug discovery and drug development areas. Starting with the screening and identification of a therapeutic agent and further measuring its in vivo and in vitro properties include: absorption, distribution, metabolism, excretion and toxicity (ADMET) and also pharmacokinetic (PK) and pharmacodynamic (PD) quantitative parameters of drug candidate. Mass spectrometry also serves as a necessary tool also to confirm purity and stability of analyzed new chemical entities (NCEs)/new molecular entities (NMEs) as well as for the analysis of degradation products from the synthesis and following on every stages of drug discovery.

Keywords: Mass spectrometry, LC-MS, drug discovery, drug development, ADMET.

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Article Details

VOLUME: 12
ISSUE: 5
Year: 2016
Page: [404 - 411]
Pages: 8
DOI: 10.2174/1573406412666160106154856
Price: $58

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