The most common and used technique to produce microfluidic devices for biomedical applications
is the soft-lithography. However, this is a high cost and time-consuming technique. Recently,
manufacturers were able to produce milling tools smaller than 100 m and consequently have
promoted the ability of the micromilling machines to fabricate microfluidic devices capable of performing
cell separation. In this work, we show the ability of a micromilling machine to manufacture
microchannels down to 30 µm and also the ability of a microfluidic device to perform partial separation
of red blood cells from plasma. Flow visualization and measurements were performed by using a
high-speed video microscopy system. Advantages and limitations of the micromilling fabrication process
are also presented.
Keywords: Biomedical applications, blood cells, cell-free layer, cells separation, micromilling, microfluidic devices.
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