Blood Flow Visualization and Measurements in Microfluidic Devices Fabricated by a Micromilling Technique

Author(s): Jaron Singhal, Diana Pinho, Raquel Lopes, Patricia C. Sousa, Valdemar Garcia, Helmut Schütte, Rui Lima, Stefan Gassmann.

Journal Name: Micro and Nanosystems

Volume 7 , Issue 3 , 2015

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The most common and used technique to produce microfluidic devices for biomedical applications is the soft-lithography. However, this is a high cost and time-consuming technique. Recently, manufacturers were able to produce milling tools smaller than 100 m and consequently have promoted the ability of the micromilling machines to fabricate microfluidic devices capable of performing cell separation. In this work, we show the ability of a micromilling machine to manufacture microchannels down to 30 µm and also the ability of a microfluidic device to perform partial separation of red blood cells from plasma. Flow visualization and measurements were performed by using a high-speed video microscopy system. Advantages and limitations of the micromilling fabrication process are also presented.

Keywords: Biomedical applications, blood cells, cell-free layer, cells separation, micromilling, microfluidic devices.

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Article Details

Year: 2015
Page: [148 - 153]
Pages: 6
DOI: 10.2174/1876402908666160106000332
Price: $58

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