Background: Many studies showed anti-inflammatory potential of thyroid hormones, but no
direct report available showing influence of thyroid hormones on inflammation state. Therefore, in
present study anti-inflammatory and antioxidative role of thyroid hormones being evaluated on rat air
pouch model of inflammation.
Methods: Reference doses of both the thyroid hormones triiodothyronine (T3) and thyroxine (T4) were administered to rat
airpouches. Air pouch model was developed by injecting air into intra-scapular region of animals, followed by
carrageenan administration (AP+C). Control animals injected only with air (AP).
Results: In AP+C, group an increase was observed in exudate levels of TNF-α, total leukocytes, polymophonuclear cells
and mononuclear cells. An increase was also observed in exudates and tissue lipid peroxidation, nitrite and reduced
glutathione. These changes were reverted back by the administration of indomethacin (I) or T3or T4. However, effect was
more pronounced in case of T3, as compared to other groups on most of the studied parameters. Histopathological changes
were also observed in AP+C group, as compared to AP alone and these alterations were also normalized by the
administration of I or T3 or T4. In silico interaction of both the thyroid hormones with cyclooxygenase (COX-2) was
studied and compared with standard drugs indomethacin and celecoxib.
Conclusion: We conclude thyroid hormones have anti-inflammatory potential i.e. mainly mediated through their structural
similarity with anti-inflammatory drugs.