Objective: The case aims to show anti-proteinuric effect of Chinese herbal
medicines (CHM) in a patient with heavy proteinuric non-IgA mesangial proliferative
glomerulonephritis (MsPGN). Subject: A 16-year-old boy was found edema in the lower
limbs and a great quantity of urine protein for 4-months and diagnosed as non-IgA MsPGN via renal biopsy
later, but there was no amelioration after receiving a shortdated comprehensive treatment including full
amount of prednisone. Then he visited Prof. Ming Wan for traditional Chinese medicine (TCM) therapy.
Interventions and outcome: This patient was treated with the integrated treatment, mainly including empirical
Chinese herbal formulas (500 mL/day for 3-months), multi-glycoside of Tripterygium wilfordii Hook.f.
(GTW) (90 mg/day for 3-months) and Losartan (50 mg/day for 3-months). His heavy proteinuria and clinical
conditions were significantly improved after continuous treatment for 3-months and basically stable for nearly
3-years during the follow-up. Conclusions: Based on a variety of conventional drugs in clinic, the combined
treatment of empirical Chinese herbal formulas and GTW was significantly effective in reducing massive
proteinuria in non-IgA MsPGN patients, which is different from hormonotherapy.
Keywords: Case report, Chinese herbal medicines, multi-glycoside of Tripterygium wilfordii Hook.f.
(GTW), Non-IgA mesangial proliferative glomerulonephritis, proteinuria.
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