Endothelial Dysfunction in Renal Failure: Current Update

Author(s): Miroslav Radenkovic, Marko Stojanovic, Milica Prostran.

Journal Name: Current Medicinal Chemistry

Volume 23 , Issue 19 , 2016

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Endothelial dysfunction is principally characterized by impaired endothelium– dependent transduction mechanisms related to vascular relaxation, as an outcome of decreased release of endothelium–derived relaxing factors, mainly nitric oxide, as well as augmented oxidative stress, increased inflammation and predominance of vascular action produced by endothelium–derived contracting factors. Current data strongly suggest that pathological development of different types of kidney impairment with further progression to renal failure includes notable vascular changes associated with endothelial dysfunction. In accordance, this scientific field represents an advancing area of investigation, involving different biomarkers of endothelial dysfunction linked to renal impairment, as well as clinical findings with new information that can provide a more comprehensive understanding of the role of endothelial dysfunction in kidney disease. With regards to quoted facts, the aim of this article was to review the latest data related to endothelial dysfunction and renal failure by selection of relevant articles released from 2010 to 2015.

Keywords: Endothelial dysfunction, renal failure, kidney disease, kidney injury, cardiorenal syndrome, diabetic nephropathy, graft failure, glomerular sclerosis.

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Article Details

Year: 2016
Page: [2047 - 2054]
Pages: 8
DOI: 10.2174/0929867323666151231095126
Price: $58

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