Spectroscopic Properties and Preparation of Some 2,3-Dimethoxybenzamide Derivatives

Author(s): Sukriye Cakmak, Halil Kutuk, Mustafa Odabasoglu, Hasan Yakan, Orhan Buyukgungor.

Journal Name: Letters in Organic Chemistry

Volume 13 , Issue 3 , 2016

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Abstract:

In this study, a series of substituted secondary amide compounds were synthesized starting from 2,3-dimethoxybenzoic acid and aniline derivatives. The structures of these synthesized compounds were determined using IR, 1H NMR and 13C NMR spectroscopy, X-ray diffraction and elemental analysis techniques.

Background: Amides are important groups in organic compounds. Amides moieties are found in many natural products. We now report a complementary study of the amide derivatives and the structures of these synthesized compounds were determined using IR, 1H NMR and 13C NMR spectroscopy, X-ray diffraction and elemental analysis techniques.

Methods: Substituted secondary amides were prepared from the corresponding 2,3-dimethoxybenzoic acid. This involved reaction of 2,3-dimethoxybenzoyl chloride with the appropriate aniline derivatives in the presence of THF to give substituted secondary amides.

Results: A summary of crystallographic data, experimental details, and refinement results for compounds are given.

Conclusion: In this study a simple, yet effective method was used for the synthesis of some benzamides from acyl chlorides with aniline and its derivatives in the presence of triethylamine. All the products were obtained with moderate-good yields.

Keywords: Acyl chloride, aniline derivatives, benzamides, secondary amides, spectroscopic properties, X-ray diffraction.

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Article Details

VOLUME: 13
ISSUE: 3
Year: 2016
Page: [181 - 194]
Pages: 14
DOI: 10.2174/1570178613666151230210931
Price: $58

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