Background: Propolis is a resinous material with complex chemical structure, produced by
bees using plant sources, displaying a wide spectrum of biological activities.
Methods: Many studies have reported the use of this compound in pharmaceutical, medicinal, veterinary
and dentistry areas, and the results have reported its pharmacological activities.
Results: Moreover, many propolis delivery systems have been proposed and evaluated, indicating that
they can be used. On the other hand, considering its chemical and physical characteristics, propolis
could be used as a material to produce micro/nano-structured pharmaceutical formulations.
Conclusion: This work reviews the recent studies of development of micro/nanostructured systems using propolis or its
byproduct. In addition, patents were reviewed and categorized.