Disulfides are used in many organic procedures and play a very important role as vulcanizing agents and
linkages for controlled drug delivery.As far as we know, no triflate-catalysed coupling of thiols has yet been reported.
Metal triflates are classified as very selective catalysts. In view of previous reports on the successful use of
Lewis acids in many organic procedures, the aim of this work was to check the activity of those catalysts in the
coupling of thiols. A new method has been disovered to obtain symmetric disulfides with yields of up to 97% under
mild conditions within a short time. Bismuth(III) triflate demonstrates the highest catalytic activity among all
of the tested triflates. This versatile and highly efficient method opens up the way to synthesize aryl disulfides, that
play a very important role as further reagents in many organic procedures. Mild conditions, low catalyst loading
and the simplicity of the experimental technique are favourable features of this reaction.
Keywords: Thiols, bismuth, metal triflates, disulfides, homogeneous coupling, S-S bond.
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