Curcumin, a natural phenolic compound mainly extracted from turmeric curcuma
longa, has been employed to prevent or treat plenty of diseases particularly cancer. It has
been proven to modulate various signal transduction pathways and exhibits antiinflammatory,
anti-oxidative, anti-metastasis anti-proliferative, anti-angiogenic in addition
anti-cancer activities. However, its poor solubility and rapid degradation severely hampers
the introduction into clinical setting. In this review, we focus on the design of polymeric micelles
(PMMCs) which are nano-scaled drug delivery vehicles and fabricated from biocompatible polymers
for efficient curcumin delivery. In particular, recent progress of curcumin loaded internal stimuli responsive
PMMCs for further intracellular uptake via internal triggers is also discussed.
Keywords: Curcumin, polymeric micelles (PMMCs), amphiphilic polymers, internal stimuli responsiveness, drug
delivery, cancer therapy.
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