Background: Chronic liver disease (such as hepatitis) is a major health problem
worldwide, especially in developing countries. Despite of the tremendous advancement in
modern medicine, there is no effective drug available that stimulates liver function. The
search of new drugs to protect hepatic injury has been of recent interest. Nigella sativa is used
as analgesic, anti-inflammatory, anti-diarrhoeal, antimicrobial, anticancer, immunomodulator,
bronchodilator, and also said to be hepatoprotective.
Objective: The aim of this work is to evaluate the hepatoprotective activity of Nigella sativa in
Wistar rats and to bring about scientific justification for the use of this drug as a hepatoprotective.
Method: Healthy Male Wistar Rats Were Treated With The Extract Of Nigella Sativa For 14
Days And On Day 14 Hepatotoxicity were induced by the administration of D-galactosamine through
Intraperitoneal (IP) route, blood was collected and analyzed for various biochemical parameters, animals were
sacrificed for histopathology, and were compared with the effect of Silymarine as a standard drug.
Result: The substantially elevated levels of aspartate amino transferase (AST), alanine aminotransferase (ALT),
alkaline phosphatase (ALP) and albumin were restored significantly by the extract of Nigella sativa.
Conclusion: Administration of N. sativa extract showed recovery against toxic effects of D-galactosamine in
rats. The hepatoprotective effect of the drug was further concluded by the histopathological examination of the
liver sections, which reveals that the normal liver shape was disturbed by D-galactosamine. The normal cellular
shape was retained as compared to silymarine, thereby confirming the protective effect of the N sativa extract.