Synthesis of Ethyl Octyl-α-Aminophosphonate Derivatives

Author(s): Ádám Tajti, Erika Bálint, György Keglevich.

Journal Name: Current Organic Synthesis

Volume 13 , Issue 4 , 2016

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

Ethyl octyl phosphite (EOP), a dialkyl phosphite with mixed alkyl groups was prepared, and utilized in the Kabachnik–Fields reaction. The condensation of EOP, paraformaldehyde and primary or secondary amines used in equimolar quantities afforded new α-aminophosphonates under microwave conditions. Methylation of the -α(alkylamino)phosphonates was also investigated. The double phospha-Mannich reaction of primary amines and two equivalents of EOP and paraformaldehyde furnished new bis(phosphonomethyl)amines.

Keywords: Ethyl octyl phosphite, Kabachnik–Fields reaction, Ethyl octyl α-aminomethyl-phosphonates, N, N-Bis(ethyloctylphosphonoylmethyl) amines, Microwave.

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 13
ISSUE: 4
Year: 2016
Page: [638 - 645]
Pages: 8
DOI: 10.2174/1570179413666151218202757

Article Metrics

PDF: 36
HTML: 1
EPUB: 1
PRC: 1