An efficient, green and facile protocol for the synthesis of pyranopyrazole derivatives
through the reaction of aromatic aldehydes, malononitrile, hydrazine hydrate and ethyl
acetoacetate was developed using Ru loaded hydroxyapatite (Ru-CaHAp) as catalyst. The
eco-friendly one-pot reactions in an ethanol-water mixture are fast (15 min) and occur at
room temperature. The catalyst was fully characterized by various techniques. The chemical
structures of the synthesized compounds were identified and confirmed by 1H, 15N and 13C
NMR, FT-IR and HR-MS spectral data. The noteworthy advantages offered by this method
are an environmentally-friendly simple procedure, mild conditions, short reaction times, recycling
of catalyst and good to excellent (89 to 98%) yield of products.
Keywords: Green Synthesis, Multicomponent Reaction, One-pot reaction, Ru-CaHAp catalyst, Recyclable, Pyranopyrazole.
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