A series of epoxyesters were lactonized by HClO4 to give corresponding ς-hydroxy-γ-lactones as a mixture of diastereoisomers: trans and cis. The mixtures of products
were separated via column chromatography. The lactones synthesized were screened for
anticancer activity against D17 and U2-OS cell lines. Only the trans isomer with naphthyl
ring was found to exhibit significant activity against both cell lines.
Keywords: Lactones, epoxyesters, aromatic ring, diastereoisomers, hydroxlactonization, antiproliferative activity.
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