Huisgen’s Cycloaddition Reactions: A Full Perspective

Author(s): Majid M. Heravi, Mehrnoush Tamimi, Hoda Yahyavi, Tayebeh Hosseinnejad.

Journal Name: Current Organic Chemistry

Volume 20 , Issue 15 , 2016

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Abstract:

Huisgen cycloaddition reaction has been originally utilized for the synthesis of 1, 2, 3-triazoles regioisomers. In this review, its stereochemistry and also mechanistical features of Huisgen cycloaddition reaction based on the quantum chemistry are highlighted. Thermal and copper catalyzed approaches to the synthesis of 1,2,3- triazoles will also be re-visited. Finally, the synthesis of alternative region-isomer, 1,5-disubstituted-1,2,3-triazoles under ruthenium catalysis and transition metal free conditions is described.

Keywords: Huisgen cycloaddition, 1, 2, 3-triazoles, quantum chemistry, copper, regioisomers, ruthenium.

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Article Details

VOLUME: 20
ISSUE: 15
Year: 2016
Page: [1591 - 1647]
Pages: 57
DOI: 10.2174/1385272820666151217183010
Price: $58

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