In our search for new compounds among the structural analogues of the Picotamide acting
on antiplatelet aggregation activities, a new series 2 of 4-ethoxyisophthal-amides were synthesized
and their in vitro anti-platelet aggregation activities were evaluated by Born’s test in comparison with
their structural analogues of the series 1 of 4-methoxyisophthal-amides. The results revealed, among
the series 2, six compounds 200, 2a, 2k, 2n, 2q and 2r displayed good antiplatelet aggregation
activities in vitro induced by 5.0 mM ADP with IC50 values ranging over 0.35 μM - 0.77 μM. And of
which, compound 2a exhibited the highest in vitro activity superior than two control drugs Picotamide and Aspirin. From
a structure-affnity-’Relationship (SAR) pointed of some insight in the view of the role played by 4-ethoxy derivatives.